Aldol Reactions by Rainer Mahrwald

By Rainer Mahrwald

Aldol Reactions presents a entire up to date evaluate of aldol reactions together with program of other steel enolates; catalytic aldol additions catalyzed through assorted Lewis acids and Lewis bases; enantioselective direct aldol additions; antibodies and enzyme catalyzed aldol additions and the hot competitive improvement of organocatalyzed aldol additions. the ability of every approach is validated by way of numerous purposes in overall synthesis of ordinary items. the professionals and cons of those methodologies with reference to stereoselectivity, regioselectivity and alertness in overall synthesis of common items are mentioned. nice significance is determined to the varied probabilities of the guide of aldol response to put in required configurations in advanced typical product synthesis.

Quality: Vector, Searchable, Bookmarked

Show description

Read Online or Download Aldol Reactions PDF

Similar organic chemistry books

Organic Chemistry: Structure and Function (6th Edition)

With authors who're either comprehensive researchers and educators, Vollhardt and Schore’s natural Chemistry is confirmed powerful for making modern natural chemistry obtainable, introducing state of the art study in a clean, student-friendly means. A wealth of particular examine instruments support scholars arrange and comprehend the immense details offered during this direction.

Organic Chemistry: Structure and Function (7th Edition)

With authors who're either entire researchers and educators, Vollhardt and Schore's natural Chemistry takes a useful staff procedure with a heavy emphasis on figuring out how the constitution of a molecule determines how that molecule will functionality in chemical reactions. via figuring out the relationship among constitution and serve as, scholars should be greater ready to appreciate mechanisms and resolve useful difficulties in natural chemistry.

Excitations in organic solids

Over the last decade our services in nanotechnology has complex significantly. the potential of incorporating within the related nanostructure diverse natural and inorganic fabrics has spread out a promising box of study, and has significantly elevated the curiosity within the examine of homes of excitations in natural fabrics.

Organic Synthesis Workbook II (No.2)

Ordinary perform makes excellent - and this can be both actual of natural synthesis. merely the varied and continuously new little methods and information make for based synthesis. wisdom of synthesis equipment, reactivities, reagents, protecting teams and masses extra is healthier got - and retained - when it comes to designated research and processing of advanced synthesis paths.

Additional resources for Aldol Reactions

Example text

R. 14). 4 Titanium Enolates 49 O O O OH X O O O O 1. Et3N 2. i-Pr2 NEt 3. 44 For the development and application of chiral oxadiazinones in enantioselective titanium enolate aldol reactions see Casper et al. 45 Chiral titanium(IV) alkoxides were used for the synthesis of optically active β-hydroxy ketones. Duthaler and coworkers generated chiral titanium enolates by transmetallation of lithium enolates of propionate with CpTi(OR2)2Cl (R2: 1, 2:5,6-di-O-isopropylidene-α-d-glucofuranose). 47,48,49,50,51 Some spectacular examples are illustrated in the following schemes in order to demonstrate the power and selectivity of these transformations.

Recently, an efficient strategy for the synthesis of syn- and anti-aldol adducts was published. 37 48 2 O O O Aldol Reactions with Preformed Enolates O O OH O OH method A or S N S + R1 N R1 N S method B Bn Bn 27 Bn 28 29 Method A: 1. TiCl4, 2. 5 equiv (–)-sparteine, 3. R1-CHO Method B: 1. 0 equiv. TiCl4, 2. 1 equiv i-Pr2NEt, 3. 12 Oxazolidinethione-based syn-selective aldol additions O O 1. TiCl4 2. i-Pr2NEt 3. r. r. = 95:5 O CO2Me N i-Pr R N O i-Pr O CO2Et 1. TiCl4 2. R-CHO 3. r. r. 14). 4 Titanium Enolates 49 O O O OH X O O O O 1.

Mori Y, Kobayashi J, Manabe K, Kobayashi S (2002) Tetrahedron 58:8263 49. Mori Y, Manabe K, Kobayashi S (2001) Angew Chem Int Ed Engl 40:2815 50. Aelvoet K, Batsanov AS, Blatch AJ, Grosjean C, Patrick LGF, Smethurst CA, Whiting A (2008) Angew Chem Int Ed 47:768 51. Burke MD, Berger EM, Schreiber SL (2003) Science 302:613 52. (a) Florence GJ, Gardner NM, Paterson I (2008) Nat Prod Rep 25:342; (b) Yeung KS, Paterson I (2005) Chem Rev 105:4237; (c) Norcross RD, Paterson I (1995) Chem Rev 95:2041 53.

Download PDF sample

Rated 4.51 of 5 – based on 11 votes